has secured a US patent for Namodenoson, its lead drug candidate, for use as an anti-obesity treatment.
Set to be issued in February 2025, the patent will expire in 2042 and covers the oral administration of the drug to reduce fat levels and body weight.
The US Patent Office has accepted patent application No 17/309,952, titled “An A3 adenosine receptor ligand for use for achieving a fat loss effect,” which is supported by the data showing Namodenoson’s ability to decrease fat cell levels by increasing adiponectin, a hormone that regulates fat production.
The drug was shown to decrease body weight in an experimental animal model of obesity.
Can-Fite CE and CFO Motti Farbstein stated: 鈥淣amodenoson is currently being developed for the treatment of MASH in a Phase IIb study where most patients are obese. We look forward to seeing the anti-obesity effect in this clinical study.鈥�
Currently under development for several conditions including metabolic dysfunction-associated steatohepatitis (MASH), pancreatic cancer and advanced liver cancer, the drug showed a favourable safety profile when taken orally, as determined in clinical studies.
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By GlobalDataIn a Phase IIa study for MASH, subjects treated with the drug experienced a 2.3% weight loss over three months, accompanied by a significant increase in serum adiponectin levels.
The drug’s selectivity to the A3 adenosine receptor, which is highly expressed in diseased cells, contributes to its safety profile.
Can-Fite has a portfolio of approved patents worldwide for clinical applications of Namodenoson.
The drug has also received orphan drug status in the US and Europe.
It also gained fast-track designation from the US Food and Drug Administration as a second-line treatment for hepatocellular carcinoma.
